RESEARCH IN THE FIELD OF THE QUANTITATIVE STRUCTURE-PROPERTY RELATIONS BY USING COMPUTATIONAL METHODS. MATHEMATICAL MODELS WITH PREDICTIVE VALUE FOR A SERIES OF COMPOUNDS WITH BIOLOGIC ACTIVITY
DIRECTOR of the PROJECT
ALLOCATED VALUE (USD)
OPREA TUDOR-IONEL
15000
Description of the project: "ATTAINING OF NEW MODELS OF SOME PROCEDURES OF QSAR, OF COMFA AND MTD METHODS AND THEIR IMPROVED VARIANTS HAVING AS THE MAIN AIM THE OBTAINMENT OF INFORMATION CONCERNING THE MECHANISM OF BIOLOGICAL ACTIVITYOR TOXICITY OF SOME CLASSES OF CHEMICAL COMPOUNDS WITH ACTION ON THE CENTRAL NERVOUS SYSTEM AND WITH ACTION ON THE CENTRAL NERVOUS SYSTEM AND WITH MUTAGENIC OR ECOTOXICOLOGICAL ACTION. THESE MODELS WERE ALSO USED TO DESIGNE AND PREVIEW CHEMICAL COMPOUNDS WITH HIGH BIOLOGICAL ACTIVITY, BUT WITH LOW TOXICITY. "
